Progeria: a cell culture study on aging.
نویسنده
چکیده
Progeria is an autosomal recessive disorder showing precocious senility. The cultured skin fibroblast from both the homozygous affected individual and the heterozygous parents can be distinguished from normals by decreased cell growth in culture. Mitotic activity, DNA synthesis, and cloning efficiency are markedly reduced.
منابع مشابه
Progeria: A Paradigm for Translational Medicine
Rare diseases are powerful windows into biological processes and can serve as models for the development of therapeutic strategies. The progress made on the premature aging disorder Progeria is a shining example of the impact that studies of rare diseases can have.
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 50 9 شماره
صفحات -
تاریخ انتشار 1971